Clinical high-risk of psychosis (CHR-P)
Conditions
Interventions
None listed
Sponsors
Amsterdam UMC
Eligibility
Age
16 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. Age 16-30 years old. 2. Dutch-speaking. 3. CHR-P only: Meets CHR-P classification criteria (i.e., the presence of attenuated psychotic symptoms and a reduction in social functioning). Of note, a CHR-P classification can also be made if a participant has a first-degree relative with a psychotic disorder, but we will only include CHR-P individuals if they themselves have experienced (attenuated) psychotic symptoms.
Exclusion criteria
Exclusion criteria: All participants: 1. Current or past (suspected) presence of a psychotic disorder, such as schizophrenia or other psychotic disorder, bipolar disorder, depressive disorder with psychotic features. 2. Current or past (suspected) presence of a neurological disorder (e.g., Parkinson*s disease, epilepsy), evidence of brain damage, and/or other medical illness (e.g., diabetes mellitus) that may affect brain function. 3. Intellectual disability (IQ
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Supplementary NM-MRI data from FEP patients and HCs: ANOVA will be used to examine the difference in NM-MRI CNR in the SN between CHR-P individuals, FEP, and HCs. For this analysis, FEP and additional HC data will be obtained from previous NM-MRI studies conducted at the Amsterdam UMC. In these supplementary analyses, we will also explore the relationship between NM-MRI signal and age, sex, drug/medication use, and psychosis symptom severity, if sufficient information on these variables is available. Finally, exploratory voxel-wise analysis of NM-MRI data will be conducted in addition to the main region of interest analysis. | — |
Primary
| Measure | Time frame |
|---|---|
| (1) Nigrostriatal dopaminergic functioning, as assessed with the NM-MRI contrast-to-noise ratio (CNR) in the substantia nigra (SN). These outcomes will be compared between CHR-P and HCs. (2) The relationship between baseline NM-MRI CNR and three-year conversion to a psychotic disorder in CHR-P individuals. The development of a (diagnosed) psychotic disorder will be evaluated through a follow-up clinical evaluation of the participant (in-person or by telephone; this is the preferred method) or by consulting their treating mental healthcare professional or general practitioner and/or through data linkage with health records provided by Statistics Netherlands. | — |
Countries
Netherlands
Outcome results
None listed