Alcoholism, alcohol use disorder
Conditions
Interventions
None listed
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: All AUD patients participants fulfil DSM-5 criteria for severe AUD, confirmed using the Mini International Neuropsychiatric Interview (MINI), a DSM-5 structured interview. Comorbidity will be defined by the following: - AUD-C (control) patients fulfil DSM-5 criteria for severe AUD - AUD-E (externalizing) patients fulfil DSM-5 criteria for severe AUD and ADHD - AUD-I (internalizing) patients fulfil DSM-5 criteria for severe AUD and depression - Between 18 and 60 years old
Exclusion criteria
Exclusion criteria: A potential participant who meets any of the following criteria will be excluded from participation in this study: Not able to provide informed consent The use of medication interfering with the dopamine and/or serotonin systems (e.g. methylphenidate or SSRIs) that cannot be discontinued (temporarily) MRI contra-indications (e.g. claustrophobia, non-removable metals in/on the body)(Ghadimi & Sapra, 2023) Other neurologic and/or hormonal disorder, such as epilepsy, diabetes or Parkinson. Acute psyhiatric episodes such as psychosis, mania, suicidality or withdrawal deliriumPregnancy Breastfeeding (History of) radiation therapy and/or exposure to other high amounts of radiation in the past 6 months (History of) cancer in the past 6 months Participation in study with radiation within the past year Allergies or adverse reactions to the tracerTraces of substances in urine measured with urine toxicology test, with the exception of positive results due to prescribed medication (e.g. benzodiazepines) or cannabis. Cannabis can be traced in urine up to 8 weeks after chronic use with the used test. Traces of alcohol with a breath test.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| we will investigate differences between adults with AUD and internalizing or externalizing mental disorders in:Brain activity and behavioural measurements during a reinforcement learning task in the MRI scanner (serotoninergic and dopaminergic system proxies)Whole brain rsFC of the raphe nuclei (serotoninergic system proxy)Whole brain rsFC of the substantia nigra (dopaminergic system proxy)Clinical characteristics, such as drug use motives | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary study objectives are to investigate differences between adults with AUD and internalizing or externalizing mental disorders in:Brain anatomy and resting state brain activity.Whole brain analysesRegion of interest approach for the dopaminergic and serotonergic related brain areas (serotoninergic and dopaminergic system proxies)Symptom severity of AUD, internalizing and externalizing mental disorders on the all brain imaging measurementsCortisol and testosterone hair concentrations and their relation to all brain imaging measurements and symptom severity of AUD, internalizing and externalizing mental disorders | — |
Countries
Netherlands
Contacts
Public ContactD.R.M. Tesselaar
Radboud Universitair Medisch Centrum
Outcome results
None listed