depression
Conditions
Interventions
The 12-16 week intervention encompasses weekly supervised 45-min exercise
sessions (moderate intensity aerobic exercise) followed by CBT, both in group
setting. Additionally, participants are prescr
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: • Adult: age 16 + • Current diagnosis of major depressive disorder, based on the Structured Clinical Interview for DSM-5 (SCID-5-S)(First et al., 1998) flanked with clinical judgement.
Exclusion criteria
Exclusion criteria: • Impossibility to obtain a valid informed consent • Physical, cognitive, or intellectual impairments interfering with participation • High health risks of physical activity (determined by clinician and/or assessed using the Physical Activity Readiness Questionnaire; Shephard et al., 1981) • Lifetime manic episode • Insufficient comprehension of Dutch language • Current admission to treatment centre
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is clinical improvement (decreases in depressive symptoms and improved CBT skills) from baseline to post-treatment measured weekly, and to 3-month follow-up. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary parameters are physical activity, mood states, emotional autobiographical memory, energy, motivation, biomarker levels of endocannabinoids and brain-derived neurotropic factor, genetics, and daily functioning. | — |
Countries
Netherlands
Contacts
Public ContactJ Vrijsen
Radboud Universitair Medisch Centrum
Outcome results
None listed