Taste steering in patients with cancer who are treated with chemotherapy: a multicentre randomized intervention trial.

Taste steering in patients with cancer who are treated with chemotherapy: a multicentre randomized intervention trial. - TASTY-steering

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON57574

Enrollment

201

Registered

2024-12-05

Start date

2025-06-06

Completion date

Unknown

Last updated

2026-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cancer malignancy cancer

Interventions

In the intervention arm, patients undergo an assessment using the online tool Smaakpupil to evaluate taste and smell characteristics. Access is exclusively reserved for participants in the study. Fo

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: * Age >=18 and <=70 years * Indication to start chemotherapy for: o Triple negative breast cancer o Testicular cancer o Stage II-IV diffuse large B cell lymphoma  - Chemotherapy scheduled during the next 6 weeks - Consuming solid foods and drinks is possible - <=50% of recommended daily intake in kcal consisting of oral nutritional  supplements - Oral mucositis grade <=2 (Common Terminology Criteria for Adverse Events,  version 5.0) - Ability to comply with all protocol-required actions - Provide written informed consent - For the intervention phase only: subjective change in taste since start of  chemotherapy

Exclusion criteria

Exclusion criteria: * Pregnancy - Currently experiencing taste or smell problems - Previous or current radiotherapy of head and neck region - Enteral feeding through tube or parenteral feeding - Participation in another clinical trial aimed at preventing or treating taste and/or smell alterations - Chronic (>1 month) high dose corticosteroids (>10 mg prednisone/day or equivalent).

Design outcomes

Primary

Measure	Time frame
Food enjoyment, measured by the subsection of the Appetite, Hunger and Sensory Perception Questionnaire (AHSP) after 6 weeks of taste steering compared with standard care.	—

Secondary

Measure	Time frame
1) Food enjoyment and food liking, measured by the questions on food enjoyment and food liking on 9-point hedonic scale; 2) Quality of life: EORTC QLQ-C30; 3) Taste and smell alterations: Chemotherapy-induced Taste Alteration Scale (ciTAS-NL); 4) Risk of malnutrition: Patient-Generated Subjective Global Assessment (PG-SGA); 5) Dry mouth feeling: Xerostomia Inventory (XI) and Regional Oral Dryness Inventory (RODI); 6) Taste and smell function; taste strips and smell sticks 7) Saliva secretion and composition; 8) Body weight. Endpoints will be measured at baseline, when taste alterations occur and after 6 weeks.	—

Measure

Time frame

1) Food enjoyment and food liking, measured by the questions on food enjoyment and food liking on 9-point hedonic scale; 2) Quality of life: EORTC QLQ-C30; 3) Taste and smell alterations: Chemotherapy-induced Taste Alteration Scale (ciTAS-NL); 4) Risk of malnutrition: Patient-Generated Subjective Global Assessment (PG-SGA); 5) Dry mouth feeling: Xerostomia Inventory (XI) and Regional Oral Dryness Inventory (RODI); 6) Taste and smell function; taste strips and smell sticks 7) Saliva secretion and composition; 8) Body weight. Endpoints will be measured at baseline, when taste alterations occur and after 6 weeks.

—

Countries

Netherlands

Contacts

Public ContactJ.J. Haan

Universitair Medisch Centrum Groningen

j.j.de.haan@umcg.nl0503612821

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP) · Data processed: Apr 17, 2026