cancer cachexia + cancer related weight loss
Conditions
Interventions
n.a.
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: To be eligible to participate in this study, a subject must meet all the following criteria: • Age >= 18 years. • Diagnosed with pancreatic cancer or colon cancer. • CT scan available. • Able to understand the Dutch language sufficiently to give informed consent and follow orders during study procedures. • Willingness to give informed consent. • Able to undergo gut permeability testing and functional muscle testing.
Exclusion criteria
Exclusion criteria: • Pancreatitis or inflammatory bowel disease. • Type I diabetes mellitus. • Peanut allergy. • Rye intolerance. • Chemotherapy in the past 8 weeks. • Large abdominal surgery in the past four weeks. • Total parenteral nutrition at day of surgery. • Systemic steroids or anti-inflammatory biologicals in the past two weeks. • Not able to perform physical activity. • Pregnant or lactating women. • Participation in possibly interfering studies within the last three months. • Inability to understand study information and/or communicate with staff.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the difference in gut permeability index between cachectic and non-cachectic cancer patients. We will assess intestinal permeability through the sugar test, the peanut test, and supportive biomarkers like lipopolysaccharide binding protein (LBP), and intestinal fatty acid binding protein (iFABP). | — |
Secondary
| Measure | Time frame |
|---|---|
| • Changes in the spatial transcriptomes of cells supporting intestinal barrier function to gain a better understanding of metabolic alterations in the various cellular structures contributing to overall intestinal tissue. • Markers associated with: (I) muscle mass and functional decline, (II) immune system activity, (III) metabolism, (IV) bile acid signaling, and (V) gut-brain signaling, in both blood and tissue samples. • Alterations in the composition and metabolism of the gut microbiome. | — |
Countries
Netherlands
Contacts
Public ContactS.S.M. Rensen
Universiteit Maastricht
Outcome results
None listed