intensive care survivors, persistent physical complaints after ICU
Conditions
Interventions
The intervention consists of a combined exercise and nutritional intervention. 
All subjects will perform 20 weeks of supervised resistance and endurance type 
exercise training 2 to 3 days per week. Leg press, leg extension, calf raises, 
chest press, shoulder press, horizontal row and vertical lateral pull exercise 
will be performed on weightlifting machines in addition to cycling on an 
ergometer. The dietary intervention aims to attain a diet that comprises 
sufficient protein, with a minimum of 1.2 g/kg bodyweight/day distributed as 
25-30 g protein per main meal, and is otherwise in line with the Dutch Healthy 
Diet guidelines. In support, subjects will consume a daily multi-nutrient 
supplement containing leucine-enriched whey protein, vitamin D, omega-3 long 
chain polyunsaturated fatty acids (n-3 lcPUFA), calcium, choline and pre- and 
probiotics, which will be ingested pre-sleep. There will be an additional 
supplement intake moment following each training session.
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Aged 18 years and older • Minimum ICU length of stay of 5 days and/or mechanically ventilated for a minimum of 2 days • Persistent physical complaints • Community-dwelling, living independently (non-assisted) • Mentally competent with a Mini-Mental State Examination (MMSE) score of >=24 • Willing to participate in a 20-week multimodal lifestyle intervention
Exclusion criteria
Exclusion criteria: • Any medical condition that may interfere with the safety of the subjects during the intervention (exercise/supplement) or any condition that interferes with assessment of the outcome parameters, in the investigators* judgement in consultation with the responsible physician or treating physician/specialist. In case of a contra-indication for MRI (e.g., a pacemaker), subjects will be excluded from this measurement but not necessarily from the study. • Known allergy to any of the ingredients present in the nutritional supplement, requiring a fiber-free diet or suffering from galactosemia or lactose intolerance. • Simultaneous use of other nutritional supplements and use of other pro- and/or prebiotics during the study period (i.e., unwillingness to stop for the duration of the study). • Current participation in other scientific research that conflicts with this study (e.g. intervention studies or weight management studies). • No permission to request information from the general practitioner/treating specialist(s) about medical history, medication use.• Not pregnant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study endpoints are muscle strength (one-repetition maximum strength test), muscle mass (whole-body MRI) and aerobic capacity (cycling VO2peak test). | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary study endpoints are overall perceived QoL, physical function, (gut, brain and metabolic) health, and skeletal muscle characteristics. | — |
Countries
Netherlands
Contacts
Public ContactB.A.J.M. Sauvé
Universiteit Maastricht
Outcome results
None listed