Post-lntensive Care Syndrome, Recovery after critical illness PICS, recovery after critical illness
Conditions
Interventions
None listed
Sponsors
Ziekenhuis Gelderse Vallei
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Age >=18 years at time of ICU admission;Received ventilatory support (IMV or NIV) within 48 hours after ICU admission with an expected duration of ventilatory support (IMV or NIV) of =48 hours during ICU stay (irrespective of ICU length of stay);ORAn expected ICU length of stay of =72 hours (irrespective of ventilatory support).
Exclusion criteria
Exclusion criteria: Concurrent participation in an intervention study with an anticipated therapeutic effect on PICS outcomes (physical functioning, cognitive functioning, or mental health status);Pre-admission diagnosis of a progressive neurological disease (e.g., Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, progressive forms of multiple sclerosis);Participants with neurological paralysis significantly affecting leg function (e.g., spinal cord injury, multiple sclerosis).Patients receiving palliative care, with a life expectancy of <3 months (e.g., hospice care or equivalent);Patients who are moribund (i.e., in the final stages of a terminal illness, with imminent death expected); Anticipated logistical limitations during recovery phase (e.g., transfer to another hospital, no fixed abode);Deemed not suitable to participate based upon the judgement of the treating intensivist.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study endpoint is physical functioning at 3-months post-ICU admission, assessed by multiple outcomes including the physical component score of the Short Form-36 questionnaire, handgrip strength, 30-second chair stand test, m. rectus femoris cross-sectional area, quadriceps muscle layer thickness, rectus femoris muscle layer thickness, rectus femoris echo-intensity, rectus femoris fascial echo-intensity, rectus femoris pinnation angle, subcutaneous tissue layer, calf circumference, and body composition. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters entail hypercatabolism, muscle metabolism, nutritional status, inflammation, gut health, cognitive function, mental health status, sleep quality, health-related quality of life, and dietary intake. These parameters will be assessed by the means of questionnaires, blood analyses and/or fecal analyses. Besides, ICU admission characteristics and clinical parameters throughout ICU stay will be recorded. | — |
Countries
Netherlands
Contacts
Public ContactNMP Overwater-van den Meijdenberg
Ziekenhuis Gelderse Vallei
Outcome results
None listed