Parkinson's disease Parkinson's disease
Conditions
Interventions
N.A.
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Cases: - Incident Parkinson's disease; o Defined as <=1 month since diagnosis was made by a neurologist in the Netherlands at the moment of recruitment. - Aged >=18 years; - Willing and able to provide informed written or digital consent. Controls: - Assigned an initial DBC code of one of the following specific set of diseases: o A median nerve neuropathy due to entrapment in the carpal tunnel (carpal tunnel syndrome), ulnar nerve neuropathy or compressive peroneal nerve neuropathy which is not related to a trauma or autoimmune disease; o Disc herniation (hernia); o Sciatica; o Lumbago; o Radiculopathy. - Aged >=18 years; - Willing and able to provide informed written or digital consent.
Exclusion criteria
Exclusion criteria: Cases: - Initially diagnosed in a non-participating centre and referred to one of the participating hospitals for follow-up care or a second opinion. - Other neurodegenerative diseases (e.g. atypical parkinsonism, ALS, or a dementia subtype which is not related to PD). Controls: - Diagnosed with Parkinson's disease at the time of inclusion; - Blood relative or spouse of a case selected by the same department of neurology to prevent over matching; - Initially diagnosed elsewhere and referred to one of the participating hospitals for follow-up care or a second opinion; - Other neurodegenerative diseases (e.g. atypical parkinsonism, ALS, dementia) at time of inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the difference in lifetime exposure to pesticides between cases and controls. Lifetime exposure will be estimated using complementary modalities that focus on occupational, residential, and household exposure. Exposure will be assessed using three complementary modalities: questionnaires, existing databases (residential history from the ‘personal records database’ and pesticide use database), and measurements (blood, saliva, hair, faeces, and via silicone wristbands). Furthermore, the study design allows assessment of other external factors that may be associated with the risk of PD. We will specifically quantify exposure to the following three groups of other external factors: heavy metals, solvents, and air pollution. If other potential risk factors of PD emerge during the study, we intend to also assess exposure to those factors by leveraging materials that have already been collected at baseline (if applicable) in order to answer future questions. Additionally, clinical progression of cases will be serially assessed for 36 months using an annual follow-up questionnaire. In the Nijmegen region, we will expand annual follow-up by using silicone wristbands and wrist-based sensors to assess exposure and clinical progression, respectively. Wrist-based sensors will also be worn in the Leiden region. | — |
Secondary
| Measure | Time frame |
|---|---|
| See above. | — |
Countries
Netherlands
Contacts
Public ContactJ.S. Bogers
Radboud Universitair Medisch Centrum
Outcome results
None listed