patients with a single liver metastasis Patients with a single liver metastasis
Conditions
Interventions
HEBIS-scan
Sponsors
Antoni van Leeuwenhoek (AVL)
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patient treated for a liver metastasis with SBRT with treatment prescription of 3 x 20 Gy.Age = 18 yearsAble to provide signed written informed consent prior to any study specific procedure
Exclusion criteria
Exclusion criteria: WHO > 2 PregnancyPrior radiation therapy of the liverLactation, unable to substitute for 24 hours Inability to cooperate with the scan process: inability to lie relatively still and in supine for 30-60 minutes or patient body habitus above scanner dimensionsExclusion criteria for HEBIS scan: GFR < 30 ml/min/1.73m2< 2 weeks after antiviral eradication therapy for hepatitis CBilirubine > 30 µmol/lRelative contra-indications (possibly affecting liver function): opiates, barbiturates, somatostatine, colestyramine, rifampicine, atropine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the change in liver function after SBRT in whole liver and regional liver function sub-volumes receiving a low/medium/high dose by measuring the hepatic mebrofenin uptake rate (MUR) divided by the body surface area (BSA) before and 3-4 months after SBRT. | — |
Countries
Netherlands
Contacts
Public ContactEAC Schouten
Antoni van Leeuwenhoek (AVL)
Outcome results
None listed