Immunity against neoantigens in CMMRD

Expression of and immunity against neoantigens in patients with constitutional mismatch repair deficiency syndrome (CMMRD); follow-up study - Immunity against neoantigens in CMMRD

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON57508

Enrollment

Registered

2025-02-04

Start date

2026-02-01

Completion date

Unknown

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bi-allelic Lynch Syndrome, bi-allelic mismatch repair deficiency (BMMRD) bi-allelic Lynch Syndrome

Interventions

None listed

Eligibility

Age

No minimum to 64 Years

Inclusion criteria

Inclusion criteria: Patients with genetically proven Constitutional Mismatch Repair Deficiency (CMMRD) Signed informed consent

Exclusion criteria

Exclusion criteria: Any form of comorbidity interfering with safe collection of bloodHaving objectives against coded storage of tissue

Design outcomes

Primary

Measure	Time frame
The primary endpoints of the study are identification of neoantigens on different tumors of CMMRD patients and the detection of pre-existing immune responses against neoantigens in these patients.	—

Countries

Netherlands

Contacts

Public ContactG Schreibelt

Radboud Universitair Medisch Centrum

gerty.schreibelt@radboudumc.nl0243617600

Outcome results