DOPAGATE

Dopaminergic mechanisms of working memory gating at the mesoscopic scale: A pharmaco-laminar fMRI study - DOPAGATE

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON57489

Enrollment

Registered

2025-02-27

Start date

2025-05-21

Completion date

Unknown

Last updated

2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cognitive impairment, working memory problems

Interventions

This is not a clinical trial, thus there is no investigational product. Participants will receive either 400mg sulpiride or placebo in the pharmaco-fMRI session, in separate sessions in a counterbalan

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Healthy volunteers between 18 and 45 years of agePredominant right-handedness18.5 < BMI < 30

Exclusion criteria

Exclusion criteria: Neuropsychiatric disorders; Relevant medical disorders; History of drug abuse; Pregnancy; Metal objects in or around the body (see section 4.3 of the Research Protocol C1 for full list of exclusion criteria)

Design outcomes

Primary

Measure	Time frame
BOLD signal measured with laminar fMRI; behavioural performance on cognitive tasks.	—

Secondary

Measure	Time frame
Behavioural performance on cognitive tasks/questionnaires.	—

Countries

Netherlands

Contacts

Public ContactH.S. Olraun

Radboud Universitair Medisch Centrum

helena.olraun@donders.ru.nl024-3668388

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)