This research does not involve patients. Not applicable
Conditions
Interventions
No interventions will be applied in studies 1-6. In studies 7 and 8, we will
test the feasibility of paired associative stimulation interventions to induce
plasticity in the SMA-SC and SMA-M1 pathwa
Sponsors
Vrije Universiteit
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Between 18-40 years old Right-handed
Exclusion criteria
Exclusion criteria: Currently pregnant A history of or 1st degree family members (parents, siblings, children) with epilepsy, convulsions or seizures Past brain surgery A pacemaker or intra-cardiac wires An implanted neurostimulator Cochlear implants Implanted medication infusion device Broken skin in the area to be contacted Multiple sclerosis Large ischaemic scars Increased intracranial pressure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are motor evoked potentials elicited using TMS and H-reflexes elicited using peripheral nerve electrical stimulation. In study 8, we will examine the effect of paired associative stimulation on performance of simple motor tasks. | — |
Secondary
| Measure | Time frame |
|---|---|
| Not applicable. | — |
Countries
Netherlands
Outcome results
None listed