colon cancer Colorectal cancer
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Age >= 21 years * A history of histologically confirmed (metastatic) colorectal adenocarcinoma * Currently diagnosed with (progressive) colorectal liver metastases (CRLM) * Signed informed consent
Exclusion criteria
Exclusion criteria: * Patients who are treated and having a response on preoperative chemotherapy, as this may have an effect on the investigated biomarker load * Illiteracy and/or insufficient proficiency of the Dutch language * Known medical history of superficial or deep skin infection after venipuncture or intravenous line that required antibiotic treatment and or hospital admittance * Known medical history of immunodeficiency or current use of medical immunosuppressants * Known medical history of blood-borne diseases such as, but not limited to, the human immunodeficiency virus, hepatitis and viral hemorrhagic fever
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint of the study is the agreement between ctDNA measurements in venous versus capillary blood to determine the feasibility of ctDNA analysis through automated capillary blood sampling. | — |
Secondary
| Measure | Time frame |
|---|---|
| Next to agreement, we will also determine the correlation between ctDNA levels in venous and capillary blood. | — |
Countries
Netherlands
Outcome results
None listed