Bilharzia schistosomiasis
Conditions
Interventions
None listed
Sponsors
IRCCS Sacro Cuore Don Calabria
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: (1) diagnosis of chronic schistosomiasis (>3 months after last potential exposure) according to site-specific diagnostic practice (2) signed informed consent (and assent for minors).
Exclusion criteria
Exclusion criteria: 1. age below 16 years; 2. exposure to praziquantel after the last potential exposure to schistosomes 3. acute infection, i.e. likely infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary objective To determine the proportion of travelers and migrants diagnosed with chronic schistosomiasis according to site-specific diagnostic practice, who have active infection at presentation (as assessed and classified by composite reference standards integrating clinical, laboratory and diagnostic features, such as microscopy, PCR (where available), POC-CCA (where available), and serum CAA results). Endpoint: proportion of enrolled participants fulfilling the composite reference standards for active infection | — |
Secondary
| Measure | Time frame |
|---|---|
| To explore the accuracy and added value of serum CAA determination as test of cure 6 weeks after the WHO standard treatment regimen (40 mg/kg single dose praziquantel), compared to conventional (microscopy) and novel methods (PCR, POC-CCA) in sites where the latter would be available. Endpoint: number of participants with initial active infection who will be CAA negative at week 6 post-treatment compared to number of participants fulfilling the composite definition of clinical and parasitological cure, and to number of negative results by each other separate diagnostic method. | — |
Countries
Netherlands
Outcome results
None listed