A-mode ultrasound measurement of jugular venous pulse wave versus invasive hemodynamics: a comparison between pulmonary hypertension and healthy controls, and hemodynamic modulation (LUMINA-study)

A-mode ultrasound measurement of jugular venous pulse wave versus invasive hemodynamics: a comparison between pulmonary hypertension and healthy controls, and hemodynamic modulation (LUMINA-study) - Sonographic JVPW vs. invasive hemodynamics in PH

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON57438

Enrollment

Registered

2024-11-06

Start date

2025-06-16

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pulmonary hypertension

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: - Age 18 years or older - Referred for RHC without vasoreactivity assessment (i.e., RHC without Flolan procedure) at Radboudumc, due to suspected pulmonary hypertension (all world health organization (WHO) groups) - Able to perform the informed consent procedure

Exclusion criteria

Exclusion criteria: A subject who meets any of the following criteria will be excluded from participation in this study: - Any contraindication for IV saline (i.e., decompensated heart failure; severe peripheral oedema; severe liver disease; hypernatremia; renal function of eGFR

Design outcomes

Primary

Measure	Time frame
The full sonographic JVPW at rest will be compared between patients and healthy controls. Invasive measurement of right ventricular end-diastolic pressure (RVEDP) through RHC will be analyzed to determine whether RVEDP can be predicted using JVPW characteristics.	—

Secondary

Measure	Time frame
JVPW assessments in patients after intravenous saline. Invasive hemodynamic parameters using RHC.	—

Countries

Netherlands

Contacts

Public ContactDHJ Thijssen

Radboud Universitair Medisch Centrum

dick.thijssen@radboudumc.nl+31 (0)6 11 21 25 34

Outcome results