Dementia frailty
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
65 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age between 65 and 80 years during the comprehensive examination at the research site - Written informed consent - Access to internet at home to fill in online questionnaires
Exclusion criteria
Exclusion criteria: - No consent of the participant to inform General Practitioner in case of abnormal results are found during the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is frailty according to the deficit accumulation model of Rockwood. This model postulates that the proportion of ageing-related health deficits, i.e. the Frailty Index (FI), reflects biological age over chronological age. For the construction of the Frailty Index (FI), we will follow the guidelines of Searle and colleagues by including health deficits on the following frailty dimensions: physical frailty, cognitive frailty, emotional frailty, sensory frailty, metabolic frailty and social frailty. Each of these health deficits can be characterize as biologically meaningful in representing multiple organ systems and accumulate with age. Each deficit was coded as 0 (absence) or 1 (presence) or when clinically relevant, as any number between 0 and 1. The frailty score will be calculated for each individual by dividing the sum of health deficits scores by the number of health deficits measured. This will result in a score between 0 (no deficits present) and 1 (all deficits present). The higher the deficit count, the frailer and more vulnerable individuals are to adverse outcomes. For clinical interpretation, people can be classified as robust (FI =0.25). | — |
Secondary
| Measure | Time frame |
|---|---|
| The following secondary parameters will be included: 1. Physical functioning a. Short Physical Performance Battery (SPPB) consisting of balance, gait speed (4 meter), and 5 chair stand up test b. Physical activity and gait speed measured with a accelerometer (MOX1 Activity Logger; Maastricht Instruments BV, Netherlands, CE certified) c. Grip strength (maximum grip strength measured at both arms 3 times with 20 sec rest intervals using Jamar handdynamometer) d. Sarcopenia (SARC-F questionnaire) e. Instrumental Activities of Daily Living (iADL questionnaire of Lawton) f. Activities of Daily Living (ADL Katz questionnaire) 2. Mental functioning a. Depressive symptoms (CES-D questionnaire) b. Loneliness (De Jong-Gierveld questionnaire) 3. Cognitive functioning a. Stroop task b. Montreal Cognitive Assessment (MOCA) c. 15-Word Verbal Learning Test 4. Well-being a. Well-being (Warwick-Edinburgh Mental Wellbeing Scale) | — |
Countries
Netherlands
Outcome results
None listed