The measurement of EEG in combination with auditive stimuli (ERP) and visual stimuli (eyetracking), and OCT to obtain reference values in healthy typically developing children (0-18 years).

The measurement of EEG in combination with auditive stimuli (ERP) and visual stimuli (eyetracking), and OCT to obtain reference values in healthy typically developing children (0-18 years). - SuperSEN study: Reference Values Project

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON57409

Enrollment

175

Registered

2024-12-06

Start date

2025-04-10

Completion date

Unknown

Last updated

2026-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy children Healthy children Hersen- en zenuwstelselontwikkeling bij kinderen

Interventions

None listed

Eligibility

Age

No minimum to 17 Years

Inclusion criteria

Inclusion criteria: Healthy children aged 0 - 18 years old

Exclusion criteria

Exclusion criteria: * Receives treatment from a (para)medical professional for a neurological disorder. * Receives treatment from a (para)medical professional for a psychiatric/mental health disorder. * Injury or diagnosis that affect eyesight (high hyperopia (>=+4 D) or high myopia ( 42 weeks

Design outcomes

Primary

Measure	Time frame
The basic visual information processing tasks trigger reflexive responses. Here, the main outcome measures are: * Performance score (target seen/unseen) * Reaction time to target fixation (milliseconds) The more complex visual information processing tasks result in (complex) gaze patterns based on scanning of pictures or videos. A relationship is assumed between a persons gaze and thoughts. Saccades, a short period in which we are unable to see, and fixations, a longer period in which we (re)direct our attention on specific visual features, are commonly used as outcome measures in eye tracking research. Here, the main outcome measures are: Performance scores (correct yes / no) * Fixation duration (milliseconds) * Gaze sequence * Number of visits to targets EEG data will be screened. Functional connectivity of EEG is a technique that is being adopted but there is not yet an established gold standard in the field (Nentwich 2020). Therefore, the start will be with the parameters phase lag index and coherence, and establish test-retest reliability in our set-up, starting with relaxed eye-closure. For ERP the main study parameters will be amplitude and latency of the N1-P2-N2 peaks. The ERP recordings will be preprocessed (e.g., averaging, filtering) and analyzed using methods such as peak latency and amplitude measurements. In OCT the total retinal thickness (TRT), the retinal nerve fiber layer thickness (RNFL) and the ganglion cell layer (GCL) thickness are the main study parameters and will be measured on the scan. The data processing is done by the principal investigator with an experienced ophthalmologist regarding OCT data. The total retinal thickness (TRT), ganglion cell layer thickness and the retinal nerve fiber layer (RNFL) obtained from the OCT will be expressed as mean ± standard deviation. A mean of all the nine areas of the ETDRS grid (circle and quadrants) will be calculated.	—

Measure

Time frame

The basic visual information processing tasks trigger reflexive responses. Here, the main outcome measures are: * Performance score (target seen/unseen) * Reaction time to target fixation (milliseconds) The more complex visual information processing tasks result in (complex) gaze patterns based on scanning of pictures or videos. A relationship is assumed between a person*s gaze and thoughts. Saccades, a short period in which we are unable to see, and fixations, a longer period in which we (re)direct our attention on specific visual features, are commonly used as outcome measures in eye tracking research. Here, the main outcome measures are: * Performance scores (correct yes / no) * Fixation duration (milliseconds) * Gaze sequence * Number of visits to targets EEG data will be screened. Functional connectivity of EEG is a technique that is being adopted but there is not yet an established gold standard in the field (Nentwich 2020). Therefore, the start will be with the parameters phase lag index and coherence, and establish test-retest reliability in our set-up, starting with relaxed eye-closure. For ERP the main study parameters will be amplitude and latency of the N1-P2-N2 peaks. The ERP recordings will be preprocessed (e.g., averaging, filtering) and analyzed using methods such as peak latency and amplitude measurements. In OCT the total retinal thickness (TRT), the retinal nerve fiber layer thickness (RNFL) and the ganglion cell layer (GCL) thickness are the main study parameters and will be measured on the scan. The data processing is done by the principal investigator with an experienced ophthalmologist regarding OCT data. The total retinal thickness (TRT), ganglion cell layer thickness and the retinal nerve fiber layer (RNFL) obtained from the OCT will be expressed as mean ± standard deviation. A mean of all the nine areas of the ETDRS grid (circle and quadrants) will be calculated.

—

Countries

Netherlands

Contacts

Public ContactL. de Jong

Erasmus MC, Universitair Medisch Centrum Rotterdam

kinderhersenlab@erasmusmc.nl0107032086

Outcome results