Using connectomes for individualised deep brain stimulation in essential tremor

Using connectomes for individualised deep brain stimulation in essential tremor - FINEST

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON57398

Enrollment

Registered

2025-03-11

Start date

2025-08-08

Completion date

Unknown

Last updated

2026-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

shaking tremor

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Pre-operative diagnosis of ET - Bilateral implantation of MR-compatible DBS electrodes (model 3389 or model B33005) - A 3T MR-compatible neurostimulator system (model B35200 - Percept PC) - The neurostimulator is implanted in the subclavicular region

Exclusion criteria

Exclusion criteria: - Inability to undergo a 1-hour MRI-scan session (including inability to lie flat for a prolonged amount of time and/or claustrophobia). - High impedance values on any contact point for both DBS electrodes, indicating open/short circuits or cable fracture. - A 3T MR-incompatible DBS system, including implantation with: o Medtronic DBS Pocket Adaptor Model 64001 or 64002 o Other discarded DBS-components in the body o Hardware from other DBS manufacturers besides Medtronic

Design outcomes

Primary

Measure	Time frame
Connectome atlas of tremor, tremor control and DBS-induced ataxia.	—

Secondary

Measure	Time frame
Objective 1.1: Visualize functional connectomes related to tremor, tremor control and DBS-induced ataxia. Objective 1.2: Integrate functional with structural connectomes. Objective 1.3: Link connectome to neuronal tremor activity.	—

Countries

Netherlands

Outcome results