delayed stomach emptying gastroparesis
Conditions
Interventions
None listed
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Adult patients (>18 years of age) - Using GLP-1 RA, with a treatment duration over 12 weeks. - Undergoing planned, elective surgery under general anaesthesia - Willing and able to provide informed consent, after adherence to standard preoperative fasting times
Exclusion criteria
Exclusion criteria: - Female who is pregnant or breast-feeding - Patients with an indication for rapid sequence induction and intubation (RSII), related to gastric emptying, such as: o A history of gastroparesis, achalasia, or neuromuscular disorders o Gastric outlet obstruction o Hiatus hernia o History of oesophageal cancer or stricture o Previous upper gastrointestinal or bariatric surgery o Ascites o Small bowel obstruction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in gastric volume in ml/kg, measured by gastric ultrasound (GU), between preoperative anaesthesiology visit (GU1, while using GLP-1 RA) and before surgery (GU2, after withholding GLP-1 RA). Patients are required to fast before both GU according to the perioperative protocol (6 hours for solids, 2 hours for clear liquids). | — |
Secondary
| Measure | Time frame |
|---|---|
| Difference for the incidence of residual gastric content (RGC), defined as >1.5ml/kg fluids or presence of solids, between GU2 and GU1. Difference in fasting blood glucose concentration comparing GU2 and GU1. | — |
Countries
Netherlands
Outcome results
None listed