sexual (dys)function sexual (dys)functioning
Conditions
Interventions
None listed
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a participant must meet all of the following criteria: • Transmasculine or gender-diverse persons assigned female at birth diagnosed with gender dysphoria; • Age >18 years; • Scheduled to begin testosterone treatment within one to three months; • Ability to provide written consent.
Exclusion criteria
Exclusion criteria: A potential participant who meets any of the following criteria will be excluded from participation in this study: • Medical or mental conditions (acute or chronic) affecting genital response; • History of hysterectomy, vaginal surgery, gynaecologic disease or malignancy, pelvic inflammatory disease, vaginal infection, or anatomical variations such as intersex conditions; • Current pregnancy or recent delivery within the last 12 months; • Self-reported genital dysphoria to the extent that participation is undesirable. • Contraindications to MRI, including pacemakers, metal implants, or severe claustrophobia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoints are clitoral and pelvic floor musculature volume (expressed in mm3) and the percentage changes in volume (expressed in %) between measurements prior to starting testosterone administration and after nine months of treatment in transmasculine and gender-diverse persons. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints are pelvic floor musculature volume and clitoral volume (expressed in mm3) and percentage changes in clitoral volume (expressed in %) during audiovisual sexual stimulation, self-reported feelings of sexual arousal during audiovisual sexual stimulation, and sexual function assessed by an adapted sexual function questionnaire. | — |
Countries
Netherlands
Outcome results
None listed