Effects of daily protein supplementation on brain function in older adults with overweight or obesity

Effects of daily protein supplementation on brain function in older adults with overweight or obesity - Protein supplementation and brain function

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON57373

Enrollment

Registered

2025-03-28

Start date

2025-05-19

Completion date

Unknown

Last updated

2026-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Insulin-resistance syndroom Metabolic syndrome Syndrome X

Interventions

Study participants will consume, in random order, twice daily (2 x 20 g) a plant protein (fava bean protein isolate), animal protein (milk protein isolate) or no extra protein (control) for two week

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Men and women, aged between 60-75 years - BMI between 25-35 kg/m2 (overweight or obese) - Fasting plasma glucose

Exclusion criteria

Exclusion criteria: - Intolerant to milk products or fava bean allergy - Vegetarians - Left-handedness - Current smoker, or smoking cessation

Design outcomes

Primary

Measure	Time frame
The primary endpoint is the difference at follow-up in the cerebral blood flow response before and after intranasal insulin administration between interventions.	—

Secondary

Measure	Time frame
Cognitive performance will be assessed with a neuropsychological test battery, while we will also focus on appetite-related brain reward activity.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP) · Data processed: Mar 20, 2026