allergic esophagitis EoE
Conditions
Interventions
A resistance measurement is done and 16 additional biopsies are taken during
the stomach examination (gastroscopy). The gastroscopy would anyway already a
potential, potential of patient participate
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: EoE patient group with dupilumab • Previous diagnosis of active EoE confirmed by histopathology e.g. presence of >15 eosinophilic granulocytes per hpf in mid or proximal oesophageal biopsies • Scheduled to start with dupilumab as regular care • 18 to 75 years of age • Written informed consent must be obtained and documented EoE patient group with active EoE • Previous diagnosis of active EoE confirmed by histopathology e.g. presence of >15 eosinophilic granulocytes per hpf in mid or proximal esophageal biopsies • Scheduled for an upper endoscopy • 18 to 75 years of age • Written informed consent must be obtained and documented Non-EoE control group • Scheduled for a upper endoscopy for other, non-EoE related, symptoms • 18 to 75 years of age • Written informed consent must be obtained and documented
Exclusion criteria
Exclusion criteria: EoE patient group • Use of oral or systemic antihistaminics, oral cromoglicates, systemic corticoster-oids, leukotriene inhibitors, or monoclonal antibodies, in the month preceding the study • Proven gastroesophageal reflux disease or other cause for esophageal eosinophil-ia • History of peptic ulcer disease • History of Barrett*s esophagus • History of GI cancer • ASA class III, IV or V Non-EoE control group • Symptoms suggestive of esophageal disease • Personal history of atopic, skin or systemic diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To investigate the effects of fully inhibiting type 2 inflammation on esophageal mucosal barrier function and inflammation in adult EoE patients. | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate the effect of type 2 inflammation and the IL4 / IL13 pathway in particular on food-induced immune responses in esophageal biopsy specimens exposed to different food allergens ex vivo. | — |
Countries
Netherlands
Outcome results
None listed