Glaucoma
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Age >= 18 years Able to understand and actively participate in experiments Signed written consent form Able to walk independently or by using a rollator Diagnosed with primary open angle glaucoma in at least one eye
Exclusion criteria
Exclusion criteria: Other ophthalmic disorders, currently and/or in the past MR contraindications (e.g., having a pacemaker or being claustrophobic) Gross abnormalities/lesions in MRI scans
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcomes are: • Retinal nerve fiber layer thickness, as assessed using OCT • Perifoveal vessel density, as assessed using OCTA • Optic disc flow index, as assessed using OCTA • Fixel based metrics in the visual system, as derived from DWI • fiber density • fiber cross section • Integrated measures | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcomes are: • Course of white matter tracts, as derived from DWI • Averaged retinal nerve fiber layer thickness, as derived from OCT • Retinal nerve fiber layer distribution, as derived from OCT • Visual field mean deviation, as derived from HFA • Degeneration of the retinal nerve fiber layer, as derived from OCT • Degeneration of pfVD and odFI, as derived from OCTA • Cerebral blood perfusion, as assessed using ASL (MRI) | — |
Countries
Netherlands
Outcome results
None listed