hersenkinetiek not applicable
Conditions
Interventions
Subjects will receive a single dose of 75µg/kg bodyweight JWH-018 (with a
maximum dose of 6 mg for individuals with a body weight of >=80 kg) and control
condition on separate testing days.
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: * Used cannabis between 1 time a month and 2 times a week during the previous year * Age between 18 and 40 years * Free from psychotropic medication * Good physical health as determined by medical examination and laboratory analysis * Absence of any major medical, endocrine and neurological condition as determined by medical examination and laboratory analysis * Normal weight, body mass index (weight/height2) between 18 and 28 kg/m2 * Written Informed Consent * Good knowledge and understanding of the English language * Participants must be willing to refrain from taking illicit psychoactive substances during the study. * Participants must be willing to drink only alcohol-free liquids and no coffee, black or green tea, or energy drinks after midnight of the evening before the study session, as well as during the study day. * Participants must be willing not to drive a traffic vehicle or to operate machines within 24 h after substance administration.
Exclusion criteria
Exclusion criteria: * History of drug addiction (determined by the medical questionnaire, drug questionnaire and medical examination). * Pregnancy or lactation or pregnancy planned during study participation. * Hypertension (diastolic > 90 mmHg; systolic > 140 mmHg). * Current or history of psychiatric disorder (determined by the medical questionnaire and medical examination). * Current presence or history of psychosis in first-degree relatives * Any chronic or acute medical condition. * History of cardiac dysfunctions (arrhythmia, ischemic heart disease,*). * For women: no use of a reliable contraceptive. * Tobacco smoking (>20 per day). * Excessive drinking (>20 alcoholic consumptions per week). Furthermore, to participate in MRI scanning a few conditions need to be satisfied by the subject. In the following cases, a MRI scan is not possible: * The subject had an operation to his head or brain. * The subject has implanted electronic devices, like a pacemaker. * The subject has an insulin pump under his skin. * The subject suffers from epilepsy. * The subject suffers from claustrophobia. * The subject has cardiological irregularities. * If there is a chance that the subject might be pregnant. * If, apart from teeth fillings and connectors, there are other metal parts in the body, like: o protheses o implants o clips on blood vessels o metal parts in the eye o spiral o metal braces o other metal objects In the following cases the researcher first needs to establish, in collaboration with the participant, whether it would be possible to have an MRI scan: * Subject has a tattoo (also permanent make-up). * Subject has one or several piercings that cannot be removed. * Subject has a metal wire behind his teeth.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the drug-induced change in neurotransmission of glutamate, GABA and dopamine which will be assessed by using MRS and resting state fMRI. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary parameters include changes in attentional salience processing, memory, JWH-018 kinetics, metabolomics, and cytokines in blood and subjective experience of the drug effects, and drug liking and wanting. | — |
Countries
Netherlands
Outcome results
None listed