food allergy
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: Aged 4-18 years Allergic to peanut diagnosed with a peanut OFC OR Allergic to cow*s milk diagnosed with a baked milk OFC Provided written informed consent
Exclusion criteria
Exclusion criteria: Under systemic immunosuppressive treatment History of hematological malignancy, immunodeficiency or autoimmune disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are serum antibodies (IgE and IgG) and blood immune cells (especially basophils, B cells, T cells and subsets therein) with specificity to the food component for which a subject is allergic. The primary endpoint is to evaluate early (at 4 months) and late (at 12 months) changes in immune response during oral immunotherapy with either peanut or baked milk in children with a mild peanut or cow's milk allergy. | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of immunological changes at baseline and over time between mild peanut allergic children treated with peanut snacks versus severe peanut allergic children remaining on a peanut free diet, as well as mild cow*s milk allergic children treated with baked milk versus severe cow*s milk allergic children remaining on a cow*s milk free diet. | — |
Countries
Netherlands
Outcome results
None listed