Niet een aandoening, maar inactiviteit en de complicaties die daarbij komen kijken. N/A
Conditions
Interventions
Participants will be randomly assigned to receive either nitrate supplements
(1097 mg NaNO3 in 140 mL water, providing 800 mg nitrate) or a placebo (1097 mg
NaCl in 140 mL water) twice daily during
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: • Aged between 18 and 40 y inclusive • BMI between 18.8 and 30 kg/m2
Exclusion criteria
Exclusion criteria: • Vegetarian/vegan • Having any food allergies related to the diets that are provided (we will provide the list of food items during the screening to assess this with the volunteers) • Smoking on a weekly basis (i.e. every week) • Diagnosed GI tract disorders or diseases • Diagnosed musculoskeletal disorders • Diagnosed metabolic disorders (e.g., diabetes) • Donated blood 2 months prior to the trial • (Family) history of thrombosis • Back complaints
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is the change in leg skeletal muscle volume (measured by MRI) before and after bedrest. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints include whole-body insulin sensitivity, muscle protein synthesis rates, mitochondrial respiration, aerobic capacity, muscle strength, blood flow, arterial stiffness, cardiac function, and endothelial function. | — |
Countries
Netherlands
Outcome results
None listed