Using Diffuse Reflectance Spectroscopy Probes to conduct Optical Measurements during Surgery for Colorectal Cancer

Using Diffuse Reflectance Spectroscopy Probes to conduct Optical Measurements during Surgery for Colorectal Cancer - DRS for In Vivo Margin Assessment in CRC

Status

Recruiting

Phases

Phase 2

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON57332

Enrollment

Registered

2025-02-28

Start date

2025-06-06

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cancer of the bowel cancer of the rectum colon cancer Colorectal Cancer rectal cancer

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Adult (eighteen years or older) written informed consent proven colorectal carcinoma undergoing open surgical resection of tumour (including advanced colorectal primary tumour, colorectal pelvic recurrence (LRRC)) and peritoneal disease (HIPEC)

Exclusion criteria

Exclusion criteria: Suspected oversensitivity to light; e.g. patient who has had photodynamic therapy Use of intravenous fluorescent agents in the area to be measured

Design outcomes

Primary

Measure	Time frame
The first outcome of the study will be the usability of the two probes, assessed using an adapted SUS-score form.	—

Secondary

Measure	Time frame
The second outcome will be the predictive value of the selected DRS probe used in conjunction with our algorithm to determine a positive resection margin (defined as tumor within 1 mm of the resection edge).	—

Countries

Netherlands

Outcome results