axial spondyloarthritis Bechterew disease
Conditions
Interventions
None listed
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, patients must meet all of the following criteria: • 18 years or older • radiographic axial spondyloarthritis according to ASAS criteria: Assessment of Spondyloarthritis International Society (ASAS) • HLA-B27 positive • Able to read, write and sufficiently communicate in Dutch • Written informed consent
Exclusion criteria
Exclusion criteria: • Contraindications to CMR or CCTA (e.g. claustrophobia, ferromagnetic implants, known allergy to iodinated or gadolinium-based contrast agents, weight or size exceeding the limits of the CMR or CCTA scanner. • Contraindications to intravenous adenosine administration (e.g. Chronic Obstructive Pulmonary Disease stage IV or asthma, systemic hypotension with mean arterial blood pressure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoints of this study are: - CAC-score -->Calciumscore (low, medium,high) | — |
Secondary
| Measure | Time frame |
|---|---|
| ->Endpoints derived from CMR (morphologic and functional parameters) ->Endpoints derived from CT coronary angiography (morphologic and functional parameters) -> Features on electrocardiogram -> The cardiovascular risk profile: a. Lipid profile: HDL cholesterol, LDL cholesterol, total cholesterol, triglycerides, apolipoprotein A-1 and apolipoprotein B b. Biomarkers of inflammation, including C-reactive protein and erythrocyte sedimentation rate c. Hemodynamic parameters: blood pressure, pulse rate. d. SCORE2 risk prediction | — |
Countries
Netherlands
Outcome results
None listed