Prostate cancer
Conditions
Interventions
Men with high risk prostate cancer with an indication for elective lymph node irradiation. Hypofractionated pelvic radiotherapy with boost to primary tumor in the prostate
Sponsors
Haaglanden Medisch Centrum (HMC)
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Men (aged >18 years of age) diagnosed within 6 months before inclusion with high risk prostate cancer. T3 based on digital rectal examination AND/OR Grade >= 4 AND/OR PSA >=20 ug/L Indication for elective lymph node irradiation (based on current clinical guidelines) OR N1 on imaging (with a maximum of 4 suspect lymph nodes)
Exclusion criteria
Exclusion criteria: Prior pelvic radiotherapy TransUrethral Resection of the Prostate (TURP) < 3 months ago Prostatectomy or other primary treatment for prostate cancer (e.g. HIFU, cryotherapy, etc) Contraindications undergoing an MRI No visible lesion on MRI in prostate for boost No PSMA-PET scan Inflammatory bowel disease Metastatic disease (M1 ) Unsuitable for SBRT or WPRT Medical history of cancer other than basal cell carcinoma of the skin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Biochemical recurrence free survival and late toxicity | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival; Metastasis Free survival at 5 years; pattern of failure (based on PSMA in case of biochemical recurrence) | — |
Countries
Netherlands
Contacts
Public ContactM.E. Mast
Haaglanden Medisch Centrum (HMC)
Outcome results
None listed