capriCORN - Comprehensive Analysis of Pathogens, Resistomes, and Inflammatory-markers in the Cornea

capriCORN - Comprehensive Analysis of Pathogens, Resistomes, and Inflammatory-markers in the Cornea - Improving Corneal Ulcer Outcomes with Pathogen and AMR Detection

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON57312

Enrollment

Registered

2025-02-21

Start date

2025-09-17

Completion date

Unknown

Last updated

2025-09-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

infectious keratitis

Interventions

None listed

Eligibility

Age

16 Years to 99 Years

Inclusion criteria

Inclusion criteria: Presence of corneal ulcer: defined as a corneal epithelial defect with underlying corneal infilitrate and signs of acute inflammation

Exclusion criteria

Exclusion criteria: Corneal perforation Inability to give consent

Design outcomes

Primary

Measure	Time frame
1. Worldwide surveillance of organisms responsible for infectious keratitis. - To identify pathogens causing infectious keratitis in an unbiased manner with MDS. - To determine the optimal diagnostic technique (stains, cultures, MDS) for corneal ulcers. - To determine the effect of seasonality on pathogen profile and visual outcomes.	—

Secondary

Measure	Time frame
2. Worldwide surveillance of antimicrobial resistance (AMR) in corneal ulcer pathogens. - To determine the frequency and richness of AMR in pathogens causing keratitis. - To determine AMR genotype and phenotype correlation with clinical outcomes. 3. To define host immune response transcriptional profiles in keratitis. - To determine the host transcriptional signatures for pathogen types. - To determine the host transcriptional signatures for clinical outcomes.	—

Measure

Time frame

2. Worldwide surveillance of antimicrobial resistance (AMR) in corneal ulcer pathogens. - To determine the frequency and richness of AMR in pathogens causing keratitis. - To determine AMR genotype and phenotype correlation with clinical outcomes. 3. To define host immune response transcriptional profiles in keratitis. - To determine the host transcriptional signatures for pathogen types. - To determine the host transcriptional signatures for clinical outcomes.

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Countries

Netherlands

Outcome results