MS Multiple Sclerosis MS
Conditions
Interventions
Active or sham TENS either in rest or in combination with foot movements.
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - age: 18-65 years - EDSS score
Exclusion criteria
Exclusion criteria: - metal or electrical implants - BMI > 40 - claustrophobia - being pregnant - having a psychiatric disorder - having cognitive or communication problems which reduces the capacity to understand instructions - having a neurological disorder other than MS - having cardiac arrhythmia - having a pacemaker or another implantable electronic apparatus.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood-oxygen-level-dependent (BOLD) activation changes and the interaction networks before, during and after active TENS and differences in activation due to active stimulation vs. sham stimulation and active stimulation on tibialis anterior vs active stimulation combined with plantar/dorsiflexion. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in brain activity and the interaction networks focussing on the thalamus (integration station of sensory input), sensory cortex (sensory awareness) and motor cortices (sensorimotor integration) before, during and after active stimulation of the quadriceps femoris vs. tibialis anterior, active stimulation of the tibialis anterior vs. plantar/dorsiflexion, sham stimulation of the tibialis anterior vs. sham stimulation combined with plantar/dorsiflexion and active stimulation in pwMS vs. active stimulation in controls. | — |
Countries
Netherlands
Contacts
Public ContactN Dreijer
Universitair Medisch Centrum Groningen
Outcome results
None listed