bronchopulmonary dysplasia
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
2 Years to 11 Years
Inclusion criteria
Inclusion criteria: BPD patients: - Diagnosis of severe BPD defined as oxygen need for >= 28 days from birth until 36 weeks postmenstrual age (PMA) AND need for >= 30% supplemental oxygen or dependence on continuous positive airway pressure, high flow nasal cannula or mechanical ventilation at 36 weeks PMA, following the 2001-National Institute of Health (NIH) definition. - Visiting the BPD follow up clinic at 8-10 years of age - Able to perform spirometry -Chest CT scan performed for clinical reasons - Written informed consent of both parent(s)/ caregiver(s)/ legal guardian as applicable Healthy controls: - Age 6-10 years - Sibs of BPD patient that will be included - Able to perform spirometry - Informed consent of both parent(s)/ caregiver(s)/ legal guardian(s) as applicable
Exclusion criteria
Exclusion criteria: BPD patients - respiratory diseases other than BPD, in particular clinical suspicion of allergic asthma Control patients: - respiratory diseases, in particular clinical suspicion of allergic asthma - born < 37 weeks of gestation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in markers of oxidative stress/ inflammation in exhaled breath between children with BPD and healthy controls. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Correlations between markers of oxidative stress/ inflammation in exhaled breath and symptoms, lung function and chest CT scores. | — |
Countries
Netherlands
Contacts
Public ContactM.W.H. Pijnenburg
Erasmus MC, Universitair Medisch Centrum Rotterdam
Outcome results
None listed