Auricular vagal nerve stimulation combined with rehabilitation to enhance functional outcome in cerebral palsy patients with upper extremity deficits (AVANS study) Part1

Auricular vagal nerve stimulation combined with rehabilitation to enhance functional outcome in cerebral palsy patients with upper extremity deficits (AVANS study) Part1 - AVANS

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON57283

Enrollment

Registered

2025-02-03

Start date

2024-10-01

Completion date

Unknown

Last updated

2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cerebral palsy spasticity

Interventions

It is unknown which aVNS stimulation intensity is the most effective in inducing cortical plasticity and improving the performance of a simple motor task. Therefore, the group will be divided into t

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Healthy subjects aged 18-70 years Proficient in Dutch language Sufficient cognitive function to follow instructions

Exclusion criteria

Exclusion criteria: History of stroke/ epilepsy or other neurological impairments Functional impairments/ pain/ sensory deficits of hand/arm. Previous injury or intervention of the vagal nerve Persons with cardiac diseases

Design outcomes

Primary

Measure	Time frame
Motor Evoked Potential (MEP) parameters will be assessed before and after the task to measure changes in cortical plasticity.	—

Secondary

Measure	Time frame
The secondary outcome parameters are the difference in motor performance during the stacking test and the difference in somatosensory evoked potential (SSEP), different stimulation intensities will be tested.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)