Hypothalamic damage in pediatric brain tumor survivors: Effects of Radiotherapy and associations with Cognitive functioning

Hypothalamic damage in pediatric brain tumor survivors: Effects of Radiotherapy and associations with Cognitive functioning - HERCules study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON57280

Enrollment

252

Registered

2024-11-11

Start date

2025-03-14

Completion date

Unknown

Last updated

2026-05-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypothalamic dysfunction, hypothalamic syndrome & damage to the hypothalamus Hypothalamic dysfunction, hypothalamic syndrome & damage to the hypothalamus

Interventions

None listed

Eligibility

Age

2 Years to 64 Years

Inclusion criteria

Inclusion criteria: Diagnosed at least five years ago with a (supra)sellar, pineal gland, or posterior fossa  tumor.

Exclusion criteria

Exclusion criteria: Neurodevelopmental disabilities and syndromic diseases affecting weight, height or neurocognitive development prediagnosis (before the brain tumor)

Design outcomes

Primary

Measure	Time frame
Normal tissue complication probability (NTCP) model for the hypothalamic syndrome in relation to cranial radiation therapy	—

Secondary

Measure	Time frame
1. Prevalence and risk factors for hypothalamic syndrome following cranial radiation therapy 2. Prevalence and risk factors for hyper/hypophagia, increased body mass index, behavioral problems, sleep disorders, temperature regulation disorders following cranial radiation therapy 3. Prevalence and risk factors for pituitary dysfunction following cranial radiation therapy 4. Prevalence and risk factors for neurocognitive dysfunction following cranial radiation therapy 5. The relationship between neurocognitive dysfunction, hypothalamic dysfunction and other risk factors following cranial radiation therapy	—

Measure

Time frame

1. Prevalence and risk factors for hypothalamic syndrome following cranial radiation therapy 2. Prevalence and risk factors for hyper/hypophagia, increased body mass index, behavioral problems, sleep disorders, temperature regulation disorders following cranial radiation therapy 3. Prevalence and risk factors for pituitary dysfunction following cranial radiation therapy 4. Prevalence and risk factors for neurocognitive dysfunction following cranial radiation therapy 5. The relationship between neurocognitive dysfunction, hypothalamic dysfunction and other risk factors following cranial radiation therapy

—

Countries

Netherlands

Contacts

Public ContactC.M. Zwaan

Prinses Máxima Centrum voor Kinderoncologie

trialmanagement@prinsesmaximacentrum.nl+31889725206

Outcome results