Huntington's Disease Huntington's Disease
Conditions
Interventions
None listed
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Individuals with an age of 21 years or above, whom have participated in TRACK-HD at the Leiden-site, with the ability to give informed consent and undergo MRI scanning.
Exclusion criteria
Exclusion criteria: • Inability to understand the information about the protocol; • Severe chorea that, in the investigator*s judgment, precludes the patient*s participation in and completion of the MRI. • Contra-indication to MRI scanning, such as: - Claustrophobia; - Pregnancy; - Pacemakers and defibrillators; - Nerve stimulators; - Intracranial clips; - Intraorbital or intraocular metallic fragments; - Cochlear implants; - Ferromagnetic implants; - Hydrocephalus pump; - Intra-utrine device (not all types); - Permanent make-up (not all); - Tattoos above the shoulders (not all).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are the neuroimaging markers, starting with the primary outcome measurement: 1. Atrophy of subcortical regions such as caudate nucleus and putamen, and cortex 2. Measures of iron accumulation in the basal ganglia and cortex 3. Levels of metabolites, especially neuroinflammation metabolites, in the putamen. We will compare these measures with the previous MRI outcome measurements from TRACK-HD. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary parameters are the clinical outcome measures, derived from the clinical assessments during this study, during TRACK-HD and the years in between during the Enroll-HD study. In addition, Q-motor assessments will be conducted and compared to available TRACK-HD measurements to evaluate longitudinal changes in objective motor function. | — |
Countries
Netherlands
Contacts
Public ContactS.C.M. Brama
Leids Universitair Medisch Centrum
Outcome results
None listed