muscle anabolism Muscle growth
Conditions
Interventions
Infusion of amino acids
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Male sex - Age between 18 and 35 y inclusive - BMI between 18.5 and 30 kg/m2 - Having given informed consent
Exclusion criteria
Exclusion criteria: - Smoking - Involved in progressive exercise - History of neuromuscular problems - Use of anticoagulants - Recent participation in amino acid tracer infusion studies - Use of medication that affects (muscle) protein metabolism (e.g.corticosteroids, NSAIDs, acne medication) - Phenylketonuria - Diagnosed with/history of liver damage - Diagnosed with/history of severe kidney damage and/or malfunction - Diagnosed with the inability to break down amino acids
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Post-prandial muscle protein synthesis rates (0-8 h) | — |
Secondary
| Measure | Time frame |
|---|---|
| Muscle protein synthesis (0-2h interval, 2-4h interval, 4-6h interval, 6-8h interval) Plasma glucose, plasma insulin, plasma amino acids, plasma amino acid concentrations, Whole-body protein kinetics (total rate of appearance, exogenous rate of appearance, endogenous rate of appearance, rate of disappearance), Whole-body protein metabolism (synthesis, breakdown, oxidation, net balance) Relevant muscle protein signalling | — |
Countries
Netherlands
Contacts
Public ContactL.J.C. van Loon
Universiteit Maastricht
Outcome results
None listed