Longevity of specific and cross-reactive cellular responses to coronaviruses in comparison to serology in COVID-19 convalescent individuals

Longevity of specific and cross-reactive cellular responses to coronaviruses in comparison to serology in COVID-19 convalescent individuals - CoviCross

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON57260

Enrollment

100

Registered

2021-05-21

Start date

2021-05-24

Completion date

Unknown

Last updated

2025-02-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coronavirus COVID-19

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: • Aged at least 18 years old • Self-reported clinical history consistent with COVID-19 • Laboratory-confirmed history of SARS-CoV-2 infection (sero-conversion)

Exclusion criteria

Exclusion criteria: There are no specific criteria for subjects to be excluded from participation in this study, as long as they adhere to the inclusion criteria mentioned above.

Design outcomes

Primary

Measure	Time frame
The main study parameter in this study is the proportion of COVID-19 convalescent individuals with a detectable SARS-CoV-2-specific adaptive immune response (T-cell and antibody responses for various antigens) at different timepoints between year one and two post initial infection.	—

Secondary

Measure	Time frame
As secondary parameters in this study the quantity, phenotype and activation profile of T-cells specific for SARS-CoV-2 and HCoVs, which will be compared at different times post SARS-CoV-2 infection and vaccination.	—

Countries

Netherlands

Outcome results