The effect of discontinuing estrogen containing oral contraceptives on corticosteroid-binding globulin and total cortisol concentrations

The effect of discontinuing estrogen containing oral contraceptives on corticosteroid-binding globulin and total cortisol concentrations - CBG normalization after cessation of COC's.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON57226

Enrollment

Registered

2024-09-23

Start date

2025-02-05

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Syndromes/disease with high or low serum cortisol levels

Interventions

N.a.

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: =/> 18 years old, female, stopping combined oral contraceptive use for at least 6 weeks

Exclusion criteria

Exclusion criteria: Switching to other hormonal contraceptives after taking COC's;  contra-indications to quit COCs;  biological factors that affect CBG concentrations (severe kidney/liver disease, active malignancy, hyperthyroidism); use of insulin, systemic glucocorticoids, mitotane, SERMs.  If patient gets pregnant during study period: exclusions of measurements after  pregnancy.

Design outcomes

Primary

Measure	Time frame
CBG en total cortisol concentrations	—

Secondary

Measure	Time frame
Secundary: VDBP -vitamin D; TBG - T4, T3; SHBG - testosterone; IGFBP3- IGF1. Tertiairy: albumin, prolactin, fT3, fT4, TSH, estradiol, progesterone, LH, FSH. HCG at last blood sampling.	—

Countries

Netherlands

Contacts

Public ContactA.C. Heijboer

Amsterdam UMC

lab-endo@amsterdamumc.nl020-5666434

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)