cardiac failure heart failure
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age >= 18 years - Give written informed consent - Scheduled for right heart catheterization for analysis of heart failure
Exclusion criteria
Exclusion criteria: - Substantiated liver disease or dysfunction including ASAT and/or ALAT > 3x the upper limit of normal (ULN) - Currently requiring dialysis or estimated GFR
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome concerns the portal pressure gradient (HPVG). HVPG represents the difference between the wedged hepatic venous pressure (WHVP) and the free hepatic venous pressure (FHVP). The WHVP is measured by occluding the right hepatic vein through the inflation of a balloon, whereas FHVP is measured without occluding it. The normal HVPG value is between 1 to 5 mmHg. A figure above this range indicates elevated portal pressure. According to their prognostic value, patients with portal hypertension can be classified in two main groups: mild or subclinical (>=6 to 9 mmHg) and clinically significant portal hypertension (>=10 mmHg). | — |
Secondary
| Measure | Time frame |
|---|---|
| - The association between the portal pressure gradient (HPVG) and renal function (eGFR) - The association between HPVG and fecal elastase (FE-1)/presence of exocrine pancreas insufficiency (EPI) - The association between HPVG and other hemodynamic indices (pulmonary capillary wedge pressure (PCWP), right atrial pressure (RAP), pulmonary arterial pressure (PAP) obtained during cardiac catheterization. | — |
Countries
Netherlands
Outcome results
None listed