juvenile dermatomyositis
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: Diagnosis juvenile dermatomyositis criteria van Bohan and Peter, ór referral to STC for non-inflammatory muscle weakness age
Exclusion criteria
Exclusion criteria: Age >18 jaar
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main objectives of the mechanism of disease part of study are: - establish the role of regulatory T cells (Treg cells) in muscle and in peripheral blood of JDM patients in active disease and in remission compared to children with non-inflammatory muscle neuromuscular disorders - responsiveness of Tregs to HSP60 and HSP70 - investigate the expression of HSP60 and HSP70 in muscle of JDM patients, compared to children with non-inflammatory neuromuscular disorders | — |
Secondary
| Measure | Time frame |
|---|---|
| - to investigate the homing of Treg cells to the site of inflammation (muscle) - to assess the local suppressive capacity of Treg cells in muscle tissue - to investigate the factors influencing the suppressive capacity of Treg cells - expression of cytokines in muscle of JDM patients - correlation between cytokine levels in serum and expression in muscle by multiplex assay - to correlate the cytokine levels to disease activity parameters (CMAS and myometrie, plus labresults) - compare these data to controls with other neuromuscular disorders than dermatomyositis. | — |
Countries
Netherlands
Outcome results
None listed