Striving for earlier detection and optimization of treatment and prognosis for patients with early-onset colorectal cancer (EOCRC); BIO-EOCRC study

Striving for earlier detection and optimization of treatment and prognosis for patients with early-onset colorectal cancer (EOCRC); BIO-EOCRC study - BIO-EOCRC

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON57209

Enrollment

300

Registered

2024-12-30

Start date

2025-01-28

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

colorectal cancer early-onset colorectal cancer

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: - Patients with locoregional or metastatic colorectal cancer - Histologically proven CRC - Age 18 - 49 years at time of first CRC diagnosis - Able to understand the informed consent form - Provide written informed consent

Exclusion criteria

Exclusion criteria: - Mentally incompetent patients based on the opinion of treating physician - Inability to understand the Dutch language

Design outcomes

Primary

Measure	Time frame
Low global QoL score measured by the EORTC-C30 questionnaire one-year after inclusion in early-onset colorectal cancer patients aged 18-49 years.	—

Secondary

Measure	Time frame
- Characteristics of the individual (sociodemographic characteristics (e.g. age, sex, work, household, BMI), disease characteristics (e.g. sidedness, tumor subsite (colon subsite or rectum), TNM stage, MSS/MSI, RAS/RAF mutational status, metastatic sites, CEA, LDH) and psychosocial characteristics). - Characteristics of the environment (Treatment characteristics & Lifestyle outcomes). - Medical history / conditions, survival outcomes (overall survival, progression free survival, disease free survival). - Microbioma outcomes - Blood and stool-based biomarkers. - Tumor genetics, biology and carcinogenesis based on WGS and tissue biopsies of tumor and surrounding mucosa.	—

Measure

Time frame

- Characteristics of the individual (sociodemographic characteristics (e.g. age, sex, work, household, BMI), disease characteristics (e.g. sidedness, tumor subsite (colon subsite or rectum), TNM stage, MSS/MSI, RAS/RAF mutational status, metastatic sites, CEA, LDH) and psychosocial characteristics). - Characteristics of the environment (Treatment characteristics & Lifestyle outcomes). - Medical history / conditions, survival outcomes (overall survival, progression free survival, disease free survival). - Microbioma outcomes - Blood and stool-based biomarkers. - Tumor genetics, biology and carcinogenesis based on WGS and tissue biopsies of tumor and surrounding mucosa.

—

Countries

Netherlands

Outcome results