Preservation of fertility in female AYA cancer patients: needs assessment, fertility, and quality of life in cancer survivors; 2-PREFER study

Preservation of fertility in female AYA cancer patients: needs assessment, fertility, and quality of life in cancer survivors; 2-PREFER study - 2-PREFER study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON57201

Enrollment

250

Registered

2024-05-05

Start date

2025-02-24

Completion date

Unknown

Last updated

2025-09-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fertility preservation

Interventions

Questionnaires and interview

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: - Women, who underwent potentially gonadotoxic treatment (chemotherapy and/or  radio-therapy) because of diagnosis of cancer  - age between 18-39 years at time of FPC - Visited the fertility clinic of the LUMC for FP(C) between 2012- september 1st 2024

Exclusion criteria

Exclusion criteria: - Non-curabel treatment - Living abroad and untraceable at time of data collection - Deceased at time of data collection or - Insufficient understanding of the Dutch language

Design outcomes

Primary

Measure	Time frame
Patients experiences and needs related to FPC and follow-up care after FP(C), assessed with self-report questionnaires, and semi-structured interviews (Q1); The fertility and obstetric out-come(s), percentage of AYAs pursuing to conceive (both with and without reproductive assis-tance) post gonadotoxic treatment, and within this group the pregnancy rate and live birth rate, assessed with self-report questionnaires (Q2); Initiating of pursuing pregnancy (yes/no) and pursuing pregnancy (months of trying to conceive); psychological factors (: anxiety- and depression levels, reproductive concern, cancer worries and decisional regret), relational fac-tors (: relationship status and duration), biographical (:age, BMI, intoxications), somatic (: medical history) are assessed with validated self-report questionnaires (Q3). Additional, we will further explore these psychological factors related to the (initiating of) pursuing pregnancy in semi-structured interviews (Q3).	—

Measure

Time frame

Patients experiences and needs related to FPC and follow-up care after FP(C), assessed with self-report questionnaires, and semi-structured interviews (Q1); The fertility and obstetric out-come(s), percentage of AYAs pursuing to conceive (both with and without reproductive assis-tance) post gonadotoxic treatment, and within this group the pregnancy rate and live birth rate, assessed with self-report questionnaires (Q2); Initiating of pursuing pregnancy (yes/no) and pursuing pregnancy (months of trying to conceive); psychological factors (: anxiety- and depression levels, reproductive concern, cancer worries and decisional regret), relational fac-tors (: relationship status and duration), biographical (:age, BMI, intoxications), somatic (: medical history) are assessed with validated self-report questionnaires (Q3). Additional, we will further explore these psychological factors related to the (initiating of) pursuing pregnancy in semi-structured interviews (Q3).

—

Secondary

Measure	Time frame
Psychological distress (anxiety and depression), desire for children; and possible mediators: reproductive concerns, gender identity concerns, and self-esteem, are assessed with validated self-report questionnaires. The moderator, parenthood status is defined by whether the AYA is a parent (yes/no) (Q4)	—

Countries

Netherlands

Contacts

Public ContactN.F. Klijn

Leids Universitair Medisch Centrum

n.f.klijn@lumc.nl071 529 9209

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)