bone marrow transplantation Clonal hematopoiesis
Conditions
Interventions
None listed
Sponsors
Prinses Máxima Centrum voor Kinderoncologie
Eligibility
Age
No minimum to 64 Years
Inclusion criteria
Inclusion criteria: Planned for first allogeneic HCT in the Princess Máxima Center.
Exclusion criteria
Exclusion criteria: - Failure of the HCT recipient and/or their legal representative to understand the patient information and informed consent form (either because of intellectual disability or language barriers). - Recipients of pharma-sponsored, genetically modified cell products (e.g., Bluebird Bio)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary aim of this study is to determine the growth trajectories of post-transplant clonal hematopoiesis, expressed as the changes in variant alele frequencies, and depicted graphically as trajectories over time. | — |
Secondary
| Measure | Time frame |
|---|---|
| We also aim to identify factors that may influence the chance of post-transplant CH. To achieve this, we will compare clinical and clone-related factors between HCT recipients with and without CH, one year after HCT. Finally, using various laboratory technologies, we will investigate the molecular processes that stimulate or inhibit the growth of CH clones. | — |
Countries
Netherlands
Outcome results
None listed