Dementia risk profile
Conditions
Interventions
Participants are randomly allocated on a 1:1 ratio to participate either in
Group A (tailored lifestyle intervention) or Group B (general health advice)
for a duration of 12 months. The lifestyle in
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1) Being >=50 years; 2) Having a diagnosis of SCD or MCI; 3) Having at least two modifiable risk factors for dementia
Exclusion criteria
Exclusion criteria: 1) Having a diagnosis of dementia; 2) Conditions affecting safe and continuous engagement in the intervention (e.g. under treatment for current malignant diseases, major psychiatric disorders (e.g. major de-pression, psychosis, bipolar disorder), other conditions preventing co-operation as judged by the local study nurse or consulted physician at the local study site; 3) Participation in any other intervention study at time of pre-screening. 4) Insufficient understanding of the Dutch language
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome will be change in participants* dementia risk profile as measured by the LIfestyle for BRAin Health (LIBRA) score between baseline and 12 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes include cognitive functions (episodic memory, executive functions, information processing speed, and attention). Other secondary outcomes include measures of body mass index (height and weight), office systolic and diastolic blood pressure, and lab measures including cholesterol levels (total, HDL, LDL, triglycerides), HbA1c levels, creatinine-based eGFR levels. Smoking, alcohol intake and current relevant medical conditions (coronary heart disease, kidney disease, type 2 diabetes, depression, hearing loss, sleep disorders) will be assessed through self-report. Additional questionnaires include health-related quality of life and capabilities, instrumental activities of daily living, health locus of control, self-efficacy, mastery, healthy diet, physical activity, cognitive stimulation, stress, and depressive symptoms, sleep quality, social support and feelings of loneliness, and lastly knowledge on dementia risk and protective factors. For cost-effectiveness, questionnaires on resource utilization, medical consumption, and productivity costs are administered. Additional measures include change in diagnosis (if applicable), demographics (age, sex, educational level, socioeconomic position (household income), paid/voluntary work hours, ethnicity, marital status, living situation), medication use, hearing loss. For process evaluation, questionnaires and interviews are administered on implementation, mechanisms of impact and contact (e.g., appointments with lifestyle coach, use of the breinzorg.nl self-management tool, use of the voucher program, experiences and usefulness, etc.). | — |
Countries
Netherlands
Contacts
Public ContactN Janssen
Universiteit Maastricht
Outcome results
None listed