Feasibility of Diffusion Tensor Imaging for radiation-induced swallowing muscle injury in head and neck cancer patients; DTI-SWALLOW

Feasibility of Diffusion Tensor Imaging for radiation-induced swallowing muscle injury in head and neck cancer patients; DTI-SWALLOW - DTI-SWALLOW

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON57180

Enrollment

Registered

2024-09-13

Start date

2024-10-18

Completion date

Unknown

Last updated

2026-03-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Swallow muscle damage after radiotherapy

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: - >18 years of age - For obj. 2 and 3 specifically: the presence of locally advanced oropharynx or oral cavity squamous cell carcinoma that will be treated with primary (chemo-) radiation

Exclusion criteria

Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: -

Design outcomes

Primary

Measure	Time frame
1. Determination of optimal DTI MRI settings for swallow musculature imaging 2. Determination of reproducibility in healthy volunteers 3. Determination of reproducibility in HNC patients 4. The quantification of radiotherapy-induced damage of the swallow musculature on DTI MRI post RT as compared to DTI MRI prior RT.	—

Secondary

Measure	Time frame
Generation of a DTI MRI sequence aimed to visualise and quantify the muscle fibres of the swallow musculature.	—

Countries

Netherlands

Outcome results