renal disease tubulopathy nierziekte
Conditions
Interventions
Niet van toepassing
Sponsors
Cruces University Hospital
Eligibility
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: • Child = 60 ml/min/1.73 m2 (for patients older than 1 year).
Exclusion criteria
Exclusion criteria: • Advanced chronic kidney disease (CKD 3-5).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - To investigate copeptin levels in pediatric polyuric tubulopathies such as Nephrogenic Diabetes Insipidus (NDI), Renal Fanconi syndrome and Bartter syndrome to use it as biomarker for the volume state of these patients. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Assess the relation between copeptin levels and other parameters of kidney function and water and salt homeostasis. In particular: o eGFR; o Serum electrolytes and acid base status; o urine and plasma osmolality; o urinary excretion of AQP2; o urinary levels of cAMP; o urinary levels of cAMP;o urine ammonium-pH indexo plasma renin and aldosterone levels; o rate of growth. | — |
Countries
Belgium, Macedonia, Netherlands, Spain, Turkey
Contacts
Public ContactM.T.P. Besouw
Universitair Medisch Centrum Groningen
Outcome results
None listed