Long-term Executive Assessment and Resilience in extremely premature-born Neonates (LEARN)

Long-term Executive Assessment and Resilience in extremely premature-born Neonates (LEARN) - LEARN

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON57161

Enrollment

218

Registered

2024-08-05

Start date

2025-08-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prematurity preterm birth Preterm birth

Interventions

None listed

Eligibility

Age

12 Years to 17 Years

Inclusion criteria

Inclusion criteria: Gestational age <28 weeks  Born between January 2009 and December 2012

Exclusion criteria

Exclusion criteria: Major chromosomal and/or congenital anomalies  Ferromagnetic implants  Claustrophobia  Parents who refuse to be informed about unexpected clinically relevant  information

Design outcomes

Primary

Measure	Time frame
The main endpoints of the study are the CANTAB scores of executive functioning (memory, attention, processing speed, cognitive flexibility, emotion recognition, inhibition, visual and social processing) in the population of exteme preterms at adolescent age.	—

Secondary

Measure	Time frame
- Quantative MRI analysis including structural, resting state functional (fMRI), diffusion imaging (DTI). - possible predictors for CANTAB scores at this age, including parental education, TEA MRI, earlier developmental scores, gender, and early-life stress (e.g.,prenatal data and stress during NICU stay).) - possible predictors for abnormal MRI scores at this age, including parental education, TEA MRI, earlier developmental scores, gender, and early-life stress (e.g.,prenatal data and stress during NICU stay).) - By post-hoc grouping of the variables into mixed effect models we hope to identify multidimensional resilient and vulnerable groups within our population , we will use variables in categories: * Clinical factors: For example, the number of days the patient required ventilation during their stay in the NICU, and the results of executive function tests. * Environmental factors: The socio-economic status (SES) of the parents. * Social factors: The educational level of the parents, and the CANTAB test for emotion recognition. * Biological factors: Such as the structure of the brain in earlier MRI scans, as well as sex differences that may play a role in the development of resilience and vulnerability.	—

Measure

Time frame

- Quantative MRI analysis including structural, resting state functional (fMRI), diffusion imaging (DTI). - possible predictors for CANTAB scores at this age, including parental education, TEA MRI, earlier developmental scores, gender, and early-life stress (e.g.,prenatal data and stress during NICU stay).) - possible predictors for abnormal MRI scores at this age, including parental education, TEA MRI, earlier developmental scores, gender, and early-life stress (e.g.,prenatal data and stress during NICU stay).) - By post-hoc grouping of the variables into mixed effect models we hope to identify multidimensional resilient and vulnerable groups within our population , we will use variables in categories: * Clinical factors: For example, the number of days the patient required ventilation during their stay in the NICU, and the results of executive function tests. * Environmental factors: The socio-economic status (SES) of the parents. * Social factors: The educational level of the parents, and the CANTAB test for emotion recognition. * Biological factors: Such as the structure of the brain in earlier MRI scans, as well as sex differences that may play a role in the development of resilience and vulnerability.

—

Countries

Netherlands

Contacts

Public ContactJ.J.D. Raijmakers

Universitair Medisch Centrum Utrecht

learn@umcutrecht.nlT +316 25710738

Outcome results