Imaging fear of painful touch: unraveling relationships between neural correlates of pain-related fear, somatosensory neuroplasticity, and sensory impairments in the context of chronic pain.

Imaging fear of painful touch: unraveling relationships between neural correlates of pain-related fear, somatosensory neuroplasticity, and sensory impairments in the context of chronic pain. - FABrIC: imaging FeAr of painful touch in the BraIn in Chronic pain patients

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON57155

Enrollment

Registered

2024-10-14

Start date

2025-07-04

Completion date

Unknown

Last updated

2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronische pijn: complex regionaal pijnsyndroom complex regional pain syndrome

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Patients: adult patients with upper limb CRPS who have chronic pain (> 3 months) in the left or right upper limb (i.e., unilateral problems) diagnosed by a physician. Age between 18 and 65 years. BMI

Exclusion criteria

Exclusion criteria: Exclusion criteria for participation in MRI studies for patients and healthy persons include: claustrophobia, active medical implants, passive implants deemed unsuitable, pregnancy; previous experience with metalworking without eye protection. Exclusion for patients and healthy persons: Cardiovascular, psychiatric, and/or neurological disease. Diagnosed with (another) chronic pain syndrome (e.g. fibromyalgia, whiplash associated disorders, chronic migraine). 65 year. Exclusion for healthy persons: injury at the fingers/hands, clinical depression or anxiety (current or past), acute or chronic pain (current or past).

Design outcomes

Primary

Measure	Time frame
Primary outcome: functional MRI blood-oxygen-level dependent (BOLD) responses in the brain to the tactile fear conditioning paradigm (acquisition, generalization, extinction phase).	—

Secondary

Measure	Time frame
Secondary outcomes and correlates: - in-scanner fear of touch self-reports - fMRI finger mapping assessing finger representations in the primary somatosensory cortex (S1) - Quantitative Sensory Testing (QST) measurements at the non-affected and affected upper limb examining tactile acuity, allodynia, and hyperalgesia - self-reported validated questionnaires using the secure online survey software Qualtrics assessing pain catastrophizing, pain-related fear, fear avoidance, positive and negative affect, optimism, resilience, trait anxiety, pain-related disability, quality of life, current pain, average pain (past week, month), and pain diagram assessing pain spreading.	—

Measure

Time frame

Secondary outcomes and correlates: - in-scanner fear of touch self-reports - fMRI finger mapping assessing finger representations in the primary somatosensory cortex (S1) - Quantitative Sensory Testing (QST) measurements at the non-affected and affected upper limb examining tactile acuity, allodynia, and hyperalgesia - self-reported validated questionnaires using the secure online survey software Qualtrics assessing pain catastrophizing, pain-related fear, fear avoidance, positive and negative affect, optimism, resilience, trait anxiety, pain-related disability, quality of life, current pain, average pain (past week, month), and pain diagram assessing pain spreading.

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Countries

Netherlands

Outcome results