Insulin resistance
Conditions
Interventions
A single test day during which participants will either receive sham-NMES followed by standard enteral nutrition (CON), whole-body NMES stimulation followed by standard enteral nutrition (WB-NMES), or
Sponsors
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Aged >=18 years • Expected to need mechanical ventilation for at least 48 hours, judged by physician • Expected to reach a Richmond Agitation-Sedation Scale (RASS) score of -4 or -5 (complete sedation), judged by physician • Informed consent obtained from the next-of-kin • Able to or are receiving enteral nutrition • Have an arterial and a venous line
Exclusion criteria
Exclusion criteria: • Spinal cord injury • Previous surgery/local wounds that prohibit NMES • Conditions that prohibit NMES (such as open wounds) • Chronic neuromuscular disorders • Acute Kidney Injury (AKI) II and III • Undergoing continuous veno-venous hemofiltration (CVVH) • Rhabdomyolysis (based on plasma creatine kinase levels) • Neuromuscular blocking agents • In the caloric restriction period of refeeding syndrome • In prone position • Burn wounds • ICD/pacemaker • Pregnant • Deemed not suitable to participate based upon the judgement of the treating intensivist
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Whole-body protein net balance (WPNB) | — |
Secondary
| Measure | Time frame |
|---|---|
| Whole body protein synthesis, breakdown, and oxidation. Forearm muscle glucoseuptake (i.e. a direct measure of muscle insulin sensitivity). | — |
Countries
Netherlands
Contacts
Public ContactM.L. Dirks
Wageningen Universiteit
Outcome results
None listed