Insight into the prevalence of unruptured intracranial aneurysms in a targeted risk-factor population: towards targeted screening

Insight into the prevalence of unruptured intracranial aneurysms in a targeted risk-factor population: towards targeted screening - Targeted risk-factor based screening for intracranial aneurysms

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON57137

Enrollment

Registered

2023-10-04

Start date

2025-12-08

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

aneurysm intracranial aneurysm Brain aneurysm

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: - Female sex - Age 50-60 years - Smoker or stopped smoking

Exclusion criteria

Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: - Known/treated brain vascular malformation/ aneurysm - Two or more first-degree relatives with diagnosed IAs - Autosomal dominant polycystic kidney disease - ASA IV-V classification (has a severe life-threatening disability, or is in a moribund state) - Implants that are not MRI compatible (i.e. pacemaker, ICM, cochlear implant, neurostimulation) - Metal foreign intra ocular body or magnetic dental implants - Claustrophobia

Design outcomes

Primary

Measure	Time frame
Main study parameter/endpoint - Number of unruptured IAs in a cohort of 55 smoking women aged 50-60 years (observational study).	—

Secondary

Measure	Time frame
Secondary study parameters/endpoints - Changes in reported quality of life before and after screening protocol in a cohort of 55 smoking women aged 50-60 years, as measured by the HQoL and EQ-5D-5L (single-arm interventional study) - Differences in the prevalence of UIAs in a Dutch cohort of smoking women aged 50-60 years compared to a Finnish cohort of women with the same characteristics - Costs of screening and potential treatment associated costs (direct and indirect) for a cohort of 55 screened women - Number of interventions to treat a diagnosed unruptured IA and associated clinical outcomes-Number of 7T MRA scans that provided improved detection and/or characterization of small vascular abnormalities and/or UIAs.	—

Measure

Time frame

Secondary study parameters/endpoints - Changes in reported quality of life before and after screening protocol in a cohort of 55 smoking women aged 50-60 years, as measured by the HQoL and EQ-5D-5L (single-arm interventional study) - Differences in the prevalence of UIAs in a Dutch cohort of smoking women aged 50-60 years compared to a Finnish cohort of women with the same characteristics - Costs of screening and potential treatment associated costs (direct and indirect) for a cohort of 55 screened women - Number of interventions to treat a diagnosed unruptured IA and associated clinical outcomes-Number of 7T MRA scans that provided improved detection and/or characterization of small vascular abnormalities and/or UIAs.

—

Countries

Netherlands

Contacts

Public ContactR.H.G.J. Lanen

Maastricht Universitair Medisch Centrum +

hanna.schenck@mumc.nl0639358605

Outcome results